MLB matchup analysis

Cubs vs Reds Prediction, Odds and Model Pick

Saturday, September 19, 2026 at Great American Ball Park · 6:40 PM ET

Watchlist

Leo prediction: Chicago Cubs moneyline

Lab Rating
6.9/10
Model lean
Cubs 71.9%
Market probability
56.1%
Model edge
+15.9%
Best moneyline
-134
Sportsbooks checked
9
Leo model
71.9%
Market
56.1%

The case for Chicago Cubs

Starting pitcher edge: 14 points
Leo gives Matthew Boyd a 14-point edge over Nick Lodolo, driven mainly by BB/9 (2.7 vs 3.9) and HR/9 (1.18 vs 1.77).
Late-inning bullpen advantage
Cincinnati Reds relievers have a 3.09 ERA over the last 7 days; Chicago Cubs relievers have a 4.26. Cincinnati Reds also have 6 arms pitching on back-to-back days, against 4 for Chicago Cubs. If this is still close after six innings, that gap favors Chicago Cubs.

The case for Cincinnati Reds

The case is thin
The model finds little going Cincinnati Reds's way — it trails on the pitching plan, bullpen, and recent form. The main path to a Cincinnati Reds win is variance.

Why it is not official

Setup quality below the bar
Lab Rating is 6.9/10, under the 7.2/10 required for an official pick.

Why the setup score is what it is

Conviction: 8.46/10
Leo's win probability for Chicago Cubs (71.9%) is well clear of a coin flip -- this is a real, stated lean, not a guess.
Pitching plan: 18.67/40
Matthew Boyd rates 64 on Leo's pitcher score, judged on its own merits (50-80 is the credited range). Average or below by that measure, so it earns little or none of the available credit here -- independent of who the opponent is throwing.
Offense: 41.48/50
Chicago Cubs's recent offensive form clearly outpaces Cincinnati Reds's over the tracked windows.

Why the price is what it is

Team strength: 54.0%
Before any pitcher or bullpen adjustment, Leo's team-strength model alone makes Chicago Cubs 54.0% to win. Everything below moves the price from this starting point.
Pitcher score gap: 14 points
The pitcher-score gap favors Chicago Cubs by 14 points. This is the biggest single mover of the price -- a large gap moves it a lot, a small gap barely moves it.
Bullpen adjustment: +0.105
The bullpen-fatigue gap between the two pens nudges the price toward Chicago Cubs. This moves the price less than the starting pitchers do, since a starter covers more of the game than the bullpen.
Net effect: 54.0% -> 71.9%
Team strength alone had Chicago Cubs at 54.0%. After the pitcher and bullpen terms, the price is 71.9% -- the same number shown as Model Lean above.
The verdict Worth monitoring, nothing more. The setup has pieces but does not add up to a bet at today's price.
Read the full model output

Chicago Cubs remains on the watchlist. Lab Rating 6.9/10: conviction 8.46, pitching plan 18.67, offense 41.48. Leo projects 71.9% against a 56.1% no-vig market number, a 15.9% model edge at -134. Chicago Cubs owns the starting pitcher edge by 14 points. Bullpen read: Supports Leo side. Chicago Cubs's pen efficiency: Average (4.5/10). Lineup check: Chicago Cubs is near its season form (+0.007 OPS); Cincinnati Reds is near its season form (+0.000 OPS).

Game information

MatchupChicago Cubs at Cincinnati Reds
DateSaturday, September 19, 2026
First pitch6:40 PM ET
VenueGreat American Ball Park
Starting pitchersMatthew Boyd vs Nick Lodolo
WeatherGame-time forecast: 88°F, 20% precipitation chance, 6 mph wind from NW.

Starting pitcher matchup

Full Pitcher Matchup Tool →
Matthew BoydCubs · LHP
vs
Nick LodoloReds · LHP
MetricCubsReds
Pitching planTraditional starterTraditional starter
Expected innings5⅔5
ThrowsLL
Leo pitcher score (higher is better)6450
ERA (lower is better)4.165.12
WHIP (lower is better)1.241.49
K/9 (higher is better)7.07.4
K-BB% (higher is better)11.4%8.5%
K% (higher is better)18.8%18.2%
BB% (lower is better)7.4%9.7%
BB/9 (lower is better)2.73.9
HR/9 (lower is better)1.21.8
Ground-ball rate49.2%52.0%
Fly-ball rate50.8%48.0%

Pitcher edge: Leo gives Matthew Boyd a 14-point edge over Nick Lodolo, driven mainly by BB/9 (2.7 vs 3.9) and HR/9 (1.18 vs 1.77).

How to read this: the scorecards above name the starters; every number lives in this table.

Strikeout Projections Full strikeout projections →

Matthew Boyd strikeouts
5.3 Leo projected Ks
Qualifying projection: OVER 4.5K · +0.8K difference
Market 4.5K · O -123 / U +105 · 5 books
Nick Lodolo strikeouts
3.6 Leo projected Ks
Qualifying projection: UNDER 4.5K · -0.9K difference
Market 4.5K · O +110 / U -135 · 5 books

Same data source as the Pitcher Matchup Tool, where every starter on the slate is compared side by side.

Cubs are 4-6 in their last 10 and averaging 5.2 runs per game over the last 15 days; Reds are 3-7 in their last 10 and averaging 4.1 runs per game over the last 15 days. On the season Cubs carry the better run differential per game (+0.92 against -0.99).

MetricCubsReds
Last 104-63-7
Last 10 by venue (away team on the road, home team at home)3-7 on the road6-4 at home
OPS, last 15 days0.7780.703
wOBA, last 15 days (hot/cold read)0.3440.310
Runs per game, last 15 days5.24.1
K% last 15 days (lower is better)17.0%27.0%

Last 15 days only. Hot and cold streaks for all 30 teams live on the Stats page.

30-day offense

Full offense tool →
Last 30 daysCubsReds
OPS0.851 (+0.080 vs szn)0.737 (+0.034 vs szn)
Runs per game6.35 (+1.015 vs szn)4.63 (+0.480 vs szn)
wOBA (model offense input)0.369 (+0.030 vs szn)0.324 (+0.013 vs szn)
K% (lower is better)17.6% (-3.5% vs szn)25.0%

Over the last 30 days the Cubs have been the better offense, 0.369 wOBA to 0.324. They are running hot against their own season line (+0.030 wOBA). Reds are striking out at 25.0% over the window — something the opposing starter can lean on.

Season profile

Full Stats page →
MetricCubsReds
Record85-6972-82
Run differential / game (team quality)+0.92-0.99
Runs scored / game (offense, season)5.334.15
Runs allowed / game (defense, season, lower better)4.425.14
Season OPS0.7710.703
K% season (lower is better)21.1%25.4%
OPS vs opposing hand (season)0.7990.742

Season-long team quality, not recent form. Run differential and run environment come from the season standings; splits for all 30 teams live on the Stats page, including the run environment table.

Every team on today's slate, on any two axes you pick. Cubs and Reds are highlighted.

Cubs
Combined risk
4.9 Normal
Fatigue
4.6 Normal
Efficiency
4.5 Average
Reds
Combined risk
8.4 High risk
Fatigue
8.8 High risk
Efficiency
5.8 Effective

Risk is what the model actually uses: fatigue blended with how well the pen has pitched. High fatigue with high efficiency is a tired pen that is still getting outs.

MetricCubsReds
Fatigue4.6/10, Normal8.8/10, High risk
Efficiency4.5/10, Average5.8/10, Effective
Combined risk4.9/10, Normal8.4/10, High risk
Relief innings, last 7 days19.032.0
Back-to-back arms46
7-day ERA4.263.09
7-day WHIP1.631.19

Fatigue measures workload. Efficiency measures recent run prevention. Combined risk is what the moneyline and totals systems use.

Run total projection

Full Totals Projections →
Leo projection
9.8
Market total
9.0
Projected away runs
5.3
Projected home runs
4.0
Over price
-113
Under price
+100
Chicago Cubs team total
5.3 projected
Line 4.5 · O -132 / U +110
Over research lean (+0.8)
Cincinnati Reds team total
4.0 projected
Line 4.5 · O +118 / U -142
No team-total lean

The model projects 0.8 runs above the market total. A research lean still requires a setup rating of at least 7.0/10. Team totals remain research-only until their graded sample is established.

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Model outputs are not guarantees. Leo provides analysis and education only. Every official pick remains visible on the Results page. 21+. If you or someone you know has a gambling problem, call 1-800-GAMBLER.